Seguridad, efectividad y control del ciclo menstrual de una preparación anticonceptiva oral monofásica con 75 mcg de gestodeno y 30 mcg de etinilestradiol / Safety, efficacy and cycle control of an oral monophasic contraceptive formulation containing gestodene 75 mcg de gestodeno y 30 mcg de etinilestradiol

Se estudió una formulación oral monofásica a base de 75 mcg de gestodeno y 30 mcg de etinilestradiol, con el objeto de probar su seguridad, eficacia y control del ciclo menstrual. En el estudio se incluyeron 67 mujeres sanas que acumularon 574 ciclos. Esta formulación mostró ser muy eficaz, ya que con el uso adecuado del método no se presentó ningún embarazo. los efectos secundarios observados fueron iguales o menores a los reportados con otros anticonceptivos hormonales orales. La administración de este nuevo preparado no modificó los parámetros hematológicos, bioquímicos o urinarios de las usuarias. Con respecto al control sobre el sangrado endometrial, las usuarias de mantuvieron dentro de un patrón menstrual considerado como acptable. En conclusión, se trata de un anticonceptivo oral que resultó ser eficaz, bien aceptado y cuyos efectos secundarios son semejantes o menores a los de otros anticonceptivos orales.

Effect of lynestrenol and mestranol on some electrolytes [sodium, potassium, calcium and magnesium] in serum, urine and aorta-experimental and clinical observation

The effect of the two synthetic steroid hormones, mestranol and lynestrenol, on sodium, potassium, calcium and magnesium on serum, urine and aorta were investigated. Mestranol alone lead to a significant rise in serum sodium and a decrease in serum potassisum but lynesdtrenol is naturitic. The sodium content of the aorta decreases with mestranol and increases with lynestrenol. Serum magnesium increases with lynestrenol. The changes with mestranol was insignificant. Ser um calcium level decreases with Lyndiol therapy; this may suggest that combined oral contraceptives do not lead to bone re-sorption. So the combined use of lynestrenol and mestranol may minimize the electrolyte disturbance which occurs with either of them

Effect of lynestrenol and mestranol on serum trace metals [copper-zinc-iron] experimental and clinical observation

1- The effect of the two synthetic steroid hormones lynestrenol and mestranol on serum copper, zinc and iron was investigated in female rats and in women. 2. There was a rise of serum copper with mestranol and a decrease in its level with lynestrenol. 3. Serum copper rises with the combination of the two hormones in Lyndiol I. This rise was progressive with the duration of therapy. 4. Serum zinc decreases with Lyndiol both in the pre-and post-menstrual period under Lyndiol I medication. In rats, serum iron rises with mestranol. The relation between serum copper and zinc can be used as a test for the selection of cases or discondinuation of treatment with oral pill, especially in rural areas with endemic bilharziasis